HEalth data LInkage for ClinicAL benefit is a training network comprising 17 academic and 9 non-academic/industry partners for early stage researchers in the field of Healthcare Data Linkage in the GDPR era.
HRB
Sep 2012
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The Tallaght Vasculitis and Allergy Group (TVA Group) aims to provide joined up, efficient and excellent care to patients with systemic vasculitic and allergic conditions by developing a strong multi-disciplinary alliance within Tallaght Hospital.
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Subsequent longitudinal sample sets are obtained over the next 5 years. To maximise its potential we now wish to target a specific patient group for recruitment: those with very active disease who have not yet been treated with immune suppressing medication. 4.
We aim to recruit, register and biobank all incident patients with systemic vasculitis in Ireland.
31/08/2017
Coordinated from Tallaght Hospital, it currently receives data and samples from five centres across Ireland and has been actively recruiting since September 2012. This is being run in collaboration with the Tallaght Vasculitis and Allergy Group
Professor Mark Little, TCD. 1/2/17
To achieve this, we will use advanced data science methodologies and Bayesian statistical techniques to develop a data architecture that curates and combines from four sources: Fixed patient-level factors (HLA-DP phenotype, granular clinical dataset obtained at diagnosis), External medical influences (maintenance immunosuppression, antibiotic prescriptions, Hospital Inpatient Enquiry records), External environmental influences, linked to patient location through time (meteorological data streams, community pathogen patterns: readily available as online data streams) and Direct patient-derived data sources (location, patient-reported quality of life and accelerometer defined activity).
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This test relies upon identification of a single protein in the urine: soluble CD163.
Edna O'Flynn award
HELICAL addresses this unmet need by developing a trans-sectoral and interdisciplinary programme with training in analysis of large datasets, using autoimmune vasculitis as a paradigm, as comprehensive biological and clinical datasets are already available. Meath Foundation
1/1/19
We expect a 50% rate of relapse after 5 years in a cohort of patients derived from the Rare Kidney Disease registry; we shall describe for the first time the relapse prodrome and define in great detail the environmental influences linking to this event. What molecular and cellular events prevent resolution of vasculitic injury after the initial insult?
To assist in answering these questions, we have set up infrastructure that allows collection of longitudinal clinical data in the form of a national registry and biobank, which is linked to a basic science laboratory.
MRCG-Irish Nephrology Society co-fund
How can we minimise the adverse events associated with existing immunosuppressive therapies? 1/2/20
Much effort is put into ensuring the first sample set is obtained before any treatment is given. We are addressing the following questions: 1.
'The DECOMPRESS project will determine the outcome of patients taking immunosuppressive medication who contract COVID-19.
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